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For Blood and Money

Billionaires, Biotech, and the Quest for a Blockbuster Drug

ebook
1 of 1 copy available
1 of 1 copy available

"A master class in the machinations of modern drug development." —Adrian Woolfson, Science

A gripping business narrative and scientific thriller about what it takes to bring a wonder drug to market—and save countless lives.

For Blood and Money tells the little-known story of how an upstart biotechnology company created a one-in-a-million cancer drug, and how the core team—denied their share of the profits—went and did it again. In this epic saga of money and science, veteran financial journalist Nathan Vardi explains how the invention of two of the biggest cancer drugs in history became (for their backers) two of the greatest Wall Street bets of all time.

In the multibillion-dollar business of biotech, where pharmaceutical companies, the government, hedge funds, and venture capitalists have spent billions on funding, experimentation, and treatments, a single molecule can stop cancer in its tracks—and make the people who find that rare molecule astonishingly rich. For Blood and Money follows a small team at a biotech start-up in California, who have found one of these rare molecules. Their compound, known as a BTK inhibitor, seems to work on a vicious type of leukemia. When patients start rising from their hospice beds, the team knows they're onto something big.

What follows is a story of genius, pathos, and drama, in which vivid characters navigate a world of corporate intrigue and ambiguous morality. Vardi's narrative immerses readers in the recent explosion of biotech start-ups. He describes the scientists, doctors, and investors who are risking everything to develop new, life-saving treatments, and introduces suffering patients for whom the stakes are life-or-death. A gripping nonfiction read, For Blood and Money illustrates why it's so hard to bring new drugs to market, explains why they are so expensive, and examines how profit-driven venture capitalists are shaping the future of medicine.

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    • Kirkus

      November 1, 2022
      The story of two small biotech firms who vied to dominate the market for a cancer drug and reaped billions of dollars in compensation. During the "great biotechnology decade of the 2010s," Pharmacyclics and Acerta, both based in California, worked feverishly to develop a new drug that used BTK inhibitors to treat chronic lymphocytic leukemia with minimal side effects. Vardi, managing editor at MarketWatch and former senior editor at Forbes, tells a fascinating story of the science behind this approach and the financial arrangements, medical controversies, regulatory processes, and business rivalries without which the two competing drugs--Imbruvica and Calquence--would not have become publicly available. Driving the quest was the possibility of huge sales; in 2020, Imbruvica had $6.6 billion in revenues. Such sales would enable the companies to be sold to bigger biotech companies, with massive payouts to investors and management. The major investor in Pharmacyclics, for example, made $3.5 billion on his $50 million investment. Vardi brings readers on to significant phone calls, places them at management meetings, and reveals in detail the deliberations that occurred among investors, medical officers, hospital doctors, and federal regulators. We learn the backstories of the key participants and the science and politics behind experimental drug trials, the competition among venture capitalists and hedge fund managers, and the strategic calculations of big pharma (Johnson & Johnson, AstraZeneca) as it engaged the "small biotech companies with experimental therapies" then dominating research and development. Tens of thousands of patients eventually benefitted, although the financial burden--a blood cancer drug can cost $10,000 per month and has to be taken for the duration of the patient's life--is staggering. The book will appeal to readers of Brendan Borrell's The First Shot and Gregory Zuckerman's A Shot To Save the World. An interesting tale of how personal ambition, scientific curiosity, and the pursuit of wealth led to life-extending drugs.

      COPYRIGHT(2022) Kirkus Reviews, ALL RIGHTS RESERVED.

    • Booklist

      December 1, 2022
      Financial journalist Vardi follows a team who created a cancer drug and were cut out of the profits but continued to work and developed another blockbuster drug. He presents his narrative in three parts, starting with a rare molecule, a BTK inhibitor, which worked on a particular type of leukemia. He documented the tedious process the biotech company had to go through to get their discovery to the in-patient study phase. Once the BTK treatment showed positive results, a frenzy began for stock shares as well as an influx of investment to get the drug developed. Vardi's fast-paced storytelling will draw readers into a world of investors, Wall Street, high-level dealmaking, and more. As the story unfolds, readers will be able to see why drug development takes so many years, millions and sometimes billions of dollars in investments, politics, casts of thousands, and dogged persistence. At the same time, Vardi unveils how the players, including the government, pharma companies, and venture capitalists, are making big profits off the success of a drug.

      COPYRIGHT(2022) Booklist, ALL RIGHTS RESERVED.

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